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Systems and methods for producing Actinium-225

專利號(hào)
US10867716B1
公開日期
2020-12-15
申請(qǐng)人
King Abdulaziz University（SA Jeddah）
發(fā)明人
Fouad Abolaban; Essam M. Banoqitah; Eslam M. Taha; Abdulsalam M. Alhawsawi; Fathi Djouider; Andrew Nisbet
IPC分類
G21G1/06; A61N5/10; G21G1/00
技術(shù)領(lǐng)域
neutron,proton,actinium,mev,racl2,neutrons,protons,energy,target,doi
地域： Jeddah

摘要

An Actinium-225 generator is provided. The generator includes a neutron source; a neutron target arranged to receive neutrons emitted from the neutron source, wherein the neutron target comprises nickel; and a proton target arranged to receive protons emitted from the neutron target, wherein the proton target comprises radium-226. Methods for producing Actinium-225 are also provided.

說明書

FIELD OF THE INVENTION

The invention is generally related to an Actinium-225 generator in which neutrons are incident on a first material to generate high energy protons, and the generated protons are then incident on a second material comprising radium-226 to produce Actinium-225.

BACKGROUND OF THE INVENTION

Recent studies have shown that mortality in men due to prostate cancer is above 358,000 worldwide, and is ranked as the second most frequent cancer after lung cancer [1]-[3]. Metastatic castration-resistant prostate cancer (mCRPC) is an advanced prostate cancer [4], [5], for which clinicians use prostate-specific membrane antigen (PSMA) as a metastatic prostate cancer indicator [6]. This advanced stage of prostate cancer can be considered as a non-curable disease depending on the PSMA level. Recent studies and clinical reports show that molecular radiotherapy using radionuclides such as Lu-177, Bi-213, and Ac-225 [7], [8] can increase the survival rate of patients [7], [9]-[12]. This involves labelling the PSMA with high Alpha or Beta emitter sources for their high Linear Energy Transfer LET and Relative Biological Effect (RBE). Acitnium-225 is the preferred radionuclide as it is an alpha emitter and has both high LET and RBE almost 100 times more than Beta emitters [6].

權(quán)利要求

1
We claim:1. An Actinium-225 generator, comprising:a neutron source;a neutron target arranged to receive neutrons emitted from the neutron source, wherein the neutron target comprises nickel, manganese, or iron; anda proton target arranged to receive protons emitted from the neutron target, wherein the proton target comprises radium-226.2. The Actinium-225 generator of claim 1, wherein the neutron target and the proton target are concentric cylinders surrounding the neutron source.3. The Actinium-225 generator of claim 1, wherein the neutron source has a source activity of at least 1E15 Bq.4. The Actinium-225 generator of claim 1, wherein the neutron source has a source activity of at least 14 MeV.5. The Actinium-225 generator of claim 1, wherein the neutron source is Californium-252.6. The Actinium-225 generator of claim 1, wherein the neutron target comprises nickel and has a thickness of 0.01-0.06 mm.7. The Actinium-225 generator of claim 1, wherein the proton target comprises RaCl2 and has a thickness of 4.5-5.5 mm.8. A method of producing Actinium-225, comprising:bombarding a neutron target with neutrons from a neutron source to produce a proton beam, wherein the neutron target comprises nickel, manganese, or iron; andbombarding a proton target with the proton beam, wherein the proton target comprises radium-226.9. The method of claim 8, wherein the neutron target and the proton target are concentric cylinders surrounding the neutron source.10. The method of claim 8, wherein a proton energy of the proton beam is 10 MeV or higher.11. The method of claim 8, wherein the neutron source has a source activity of at least 1E15 Bq.12. The method of claim 8, wherein the neutron source has a source activity of at least 14 MeV.13. The method of claim 8, wherein the neutron source is Californium-252.14. The method of claim 8, wherein the neutron target comprises nickel and has a thickness of 0.01-0.06 mm.15. The method of claim 8, wherein the proton target comprises RaCl2 and has a thickness of 4.5-5.5 mm.
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