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Multi detector mass spectrometer and spectrometry method filter

專利號
US10867780B2
公開日期
2020-12-15
申請人
Thermo Fisher Scientific (Bremen) GmbH; The University of Bristol(DE Bremen GB Bristol)
發(fā)明人
Johannes Schwieters; Timothy Richard Elliott; Christopher David Coath
IPC分類
H01J49/28; H01J49/02; H01J49/00; H01J49/10
技術(shù)領(lǐng)域
mass,collision,ion,ions,quadrupole,cell,faraday,in,analyser,filter
地域: Bremen

摘要

The present invention can be directed to a mass spectrometer, relevant parts thereof like replacement kits or upgrading kits and/or mass spectrometry methods. A mass spectrometer according to the present invention can comprise at least one ion source for generating a beam of ions from a sample. Moreover at least one mass filter downstream of the ion source can be provided and adapted to select ions from the beam by their mass-to-charge ratio (m/z). Furthermore at least one collision cell arranged downstream of the mass filter can be arranged. At least one sector field mass analyser arranged downstream of the collision cell can be further provided and at least one ion multicollector comprising a plurality of ion detectors arranged downstream of the mass analyser, for detecting a plurality of different ion species in parallel and/or simultaneously.

說明書

An electro-static sector 41 can be arranged downstream of the accelerator 40 in order to disperse ions by the energy and thus provide focusing for ions of the same energy. Downstream the electro-static sector 41 a focussing lens 42 can be arranged upstream a magnetic sector 43. The magnetic sector 43 can disperse the ions by masses (mass-to-charge ratios). The electro-static sector 41 and the magnetic sector 43 can be arranged in a so-called Nier-Johnson-Geometry for use of a scanning magnetic sector 43 in order to sequentially focus ions with different m/z ratios.

Downstream the magnetic sector 43, dispersion optics 44 can be arranged to change the mass dispersion and improve peak detection. Such optics are employed e.g. on the Neptune? multi-collector mass spectrometer (Thermo Scientific). Further downstream, a detector platform 50 can be arranged. The instrument can, e.g., cover 16% relative mass range along the focal plane. The detector platform 50 can comprise 9 Faraday cups plus a maximum of 8 (eight) ion counters.

FIG. 2 shows an enlarged portion of the elements according to FIG. 1. As mentioned, the ICP torch 10 and the ICP interface comprise sampler cone 11 the one or more skimmer cones 12, 14 and/or extraction lens 13 and/or another ion optical device 14 can be arranged. The quadrupole mass filter 20 can be arranged downstream of the ICP interface 11, 12, 13, 14.

權(quán)利要求

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