Electrospray ionization interface to high pressure mass spectrometry and related methods
摘要
說明書
In some embodiments, the ESI device 20 extends into the vacuum chamber 12 with the mass analyzer 30 shown, for example, as a capillary tube 20t, in
The wall of the vacuum chamber 12w can include an aperture for receiving a segment of the microchip 20 via a vacuum seal 18. In some embodiments, the vacuum seal 18 can include an O-ring, gasket or other seal that can extend about an external surface of the microchip 20c. The seal 18 may conform to the shape of the microchip 20c or segment thereof. In some particular embodiments, the seal 18 can be rectangular. The chip 20 can be oriented horizontally, vertically or even at an angle between vertical and horizontal with respect to the vacuum chamber 12. The rectangular shape of the seal 18 may be appropriate where an entire forward end of a rectangular shaped microchip 20c is held in the vacuum chamber 12. The seal 18 can be on the microchip 20 and/or on the wall 12w of the chamber 12w and/or housing 10h or in a vacuum fitting that is sized and configured to matably, sealably receive an end portion of the microship 20c.
