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Systems and methods for encoding image features of high-resolution digital images of biological specimens

專利號(hào)
US11176412B2
公開(kāi)日期
2021-11-16
申請(qǐng)人
Ventana Medical Systems, Inc.(US AZ Tucson)
發(fā)明人
Yao Nie
IPC分類
G06K9/00; G06K9/62; G06T7/11; G06K9/46
技術(shù)領(lǐng)域
superpixel,image,clustering,centroid,clusters,in,cluster,vectors,vector,biological
地域: AZ AZ Tucson

摘要

An image analysis system for analyzing biological specimen images is disclosed. The system may include: a superpixel generator configured to obtain a biological specimen image and group pixels of the biological specimen image into a plurality of superpixels; a feature extractor configured to extract, from each superpixel in the plurality of superpixels, a feature vector comprising a plurality of image features; a clustering engine configured to assign the plurality of superpixels to a predefined number of clusters, each cluster being characterized by a centroid vector of feature vectors of superpixels assigned to the cluster; and a storage interface configured to store, for each superpixel in the plurality of superpixels, clustering information identifying the one cluster to which the superpixel is assigned. The system may also include a graph engine configured construct a graph based on the stored information, and use the graph to perform a graph-based image processing task.

說(shuō)明書(shū)

After feature vectors have been calculated for each superpixel by feature extractor 111, the feature vectors can be provided to clustering engine 112. Clustering engine 112 may then cluster the superpixels by assigning each superpixel to a particular cluster of superpixels. Thus, for example, clustering engine 112 may generally cluster N superpixels into K clusters. The clustering may be performed based on the similarities of the feature vectors associate with each superpixel. For example, each cluster may be associated with a centroid vector, such that feature vector of each superpixel in the cluster is closest to the centroid vector of that cluster than to the centroid of any other cluster.

In some embodiments, the number of clusters K can be predefined for a particular application. For example, for a typical image segmentation problem in which the image needs to be segmented into a predefined maximum number of different regions (e.g., 5), K clusters can be set to a number that is larger but is within the order of magnitude of the predefined maximum number of regions (e.g., 15, 20, or 25). In some examples, the number of clusters K can be dynamically adjusted based on user input.

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