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Systems and methods for encoding image features of high-resolution digital images of biological specimens

專利號
US11176412B2
公開日期
2021-11-16
申請人
Ventana Medical Systems, Inc.(US AZ Tucson)
發(fā)明人
Yao Nie
IPC分類
G06K9/00; G06K9/62; G06T7/11; G06K9/46
技術(shù)領(lǐng)域
superpixel,image,clustering,centroid,clusters,in,cluster,vectors,vector,biological
地域: AZ AZ Tucson

摘要

An image analysis system for analyzing biological specimen images is disclosed. The system may include: a superpixel generator configured to obtain a biological specimen image and group pixels of the biological specimen image into a plurality of superpixels; a feature extractor configured to extract, from each superpixel in the plurality of superpixels, a feature vector comprising a plurality of image features; a clustering engine configured to assign the plurality of superpixels to a predefined number of clusters, each cluster being characterized by a centroid vector of feature vectors of superpixels assigned to the cluster; and a storage interface configured to store, for each superpixel in the plurality of superpixels, clustering information identifying the one cluster to which the superpixel is assigned. The system may also include a graph engine configured construct a graph based on the stored information, and use the graph to perform a graph-based image processing task.

說明書

In some embodiments, clustering engine 112 may use a non-weighted Euclidean distance, where each image feature in the feature vector has the same weight. In other embodiments, however, clustering engine 112 may use a weighted Euclidean (or non-Euclidean) distance during clustering, weighing some image features higher than other. For example, in some embodiments, clustering engine 112 may determine and assign different feature weights to different image features. For example, clustering engine 112 may collect (e.g., using user interface module 115) at least one annotation (e.g., a scribble or a line) identifying a plurality of similar superpixels, i.e., superpixels that the user considers to belong to the same segment or category. Clustering engine 112 may then determine, based on the feature vectors of the similar superpixels, which image features in the feature vectors should be assigned higher feature weights than others. Some methods and systems of determining and assigning weights to different image features are described in U.S. Provisional Patent Application No. 62/136,381 and in International Patent Publication No. WO/2016150873, the entireties of which are hereby incorporated by reference.

In some embodiments, in addition to clustering the superpixels by assigning each superpixel into one of K clusters (where K is a predefined parameter), clustering engine 112 may precalculate the distances between every two clusters, i.e., the distances between centroid vectors of each cluster and each other cluster. Thus, in some embodiments, clustering engine 112 may precalculate at least K(K?1)/2 distances, which is the number of different combinations of two clusters within K clusters. Clustering engine 112 may calculate the distances between the clusters using the same measure of distance that was used for generating the clusters, for example.

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