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Systems and methods for encoding image features of high-resolution digital images of biological specimens

專利號(hào)
US11176412B2
公開日期
2021-11-16
申請(qǐng)人
Ventana Medical Systems, Inc.(US AZ Tucson)
發(fā)明人
Yao Nie
IPC分類
G06K9/00; G06K9/62; G06T7/11; G06K9/46
技術(shù)領(lǐng)域
superpixel,image,clustering,centroid,clusters,in,cluster,vectors,vector,biological
地域: AZ AZ Tucson

摘要

An image analysis system for analyzing biological specimen images is disclosed. The system may include: a superpixel generator configured to obtain a biological specimen image and group pixels of the biological specimen image into a plurality of superpixels; a feature extractor configured to extract, from each superpixel in the plurality of superpixels, a feature vector comprising a plurality of image features; a clustering engine configured to assign the plurality of superpixels to a predefined number of clusters, each cluster being characterized by a centroid vector of feature vectors of superpixels assigned to the cluster; and a storage interface configured to store, for each superpixel in the plurality of superpixels, clustering information identifying the one cluster to which the superpixel is assigned. The system may also include a graph engine configured construct a graph based on the stored information, and use the graph to perform a graph-based image processing task.

說明書

FIG. 3C further illustrates some embodiments discussed above. FIG. 3C shows superpixel generator 110 obtaining an exemplary biological sample image 310 and producing a plurality of superpixels 320 based on biological sample image 310. Feature extractor 111 can then obtain the plurality of superpixels 320 and extract feature vectors 330 for all the superpixels. Clustering engine 112 can obtain feature vectors 330, and based at least on feature vectors 330, generated a predefined number of (in this example, four) clusters A, B, C, and D arranged, for example, as illustrated in clustering information 350 and visualized by clustering information image 340. As discussed above, each cluster can be characterized or represented by a centroid vector, as illustrated in exemplary centroid vector table 370. Clustering engine 112 can also precalculate distances between each pair of different clusters, as illustrated in exemplary distance table 360. Storage interface 113 can then store clustering information 350 into memory 116 (or any other memory). As discussed above, storage interface 113 can also store into memory distance table 360 and/or centroid vector table 370.

FIG. 3D shows graph engine 112 retrieving from memory 116 (through storage interface 113) clustering information 350, and distance table 360 and/or centroid vector table 370. Based at least on this information, graph engine 112 generates an exemplary graph 380.

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