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Systems and methods for encoding image features of high-resolution digital images of biological specimens

專利號
US11176412B2
公開日期
2021-11-16
申請人
Ventana Medical Systems, Inc.(US AZ Tucson)
發(fā)明人
Yao Nie
IPC分類
G06K9/00; G06K9/62; G06T7/11; G06K9/46
技術(shù)領(lǐng)域
superpixel,image,clustering,centroid,clusters,in,cluster,vectors,vector,biological
地域: AZ AZ Tucson

摘要

An image analysis system for analyzing biological specimen images is disclosed. The system may include: a superpixel generator configured to obtain a biological specimen image and group pixels of the biological specimen image into a plurality of superpixels; a feature extractor configured to extract, from each superpixel in the plurality of superpixels, a feature vector comprising a plurality of image features; a clustering engine configured to assign the plurality of superpixels to a predefined number of clusters, each cluster being characterized by a centroid vector of feature vectors of superpixels assigned to the cluster; and a storage interface configured to store, for each superpixel in the plurality of superpixels, clustering information identifying the one cluster to which the superpixel is assigned. The system may also include a graph engine configured construct a graph based on the stored information, and use the graph to perform a graph-based image processing task.

說明書

It is appreciated based on the foregoing discussion that in some embodiments, the method may include different or additional steps, such as retrieving the centroid vector of each cluster and/or the distances between each two clusters, and using the centroid vector of each cluster and/or the distances between each clusters to construct a graph, and performing a graph-based image processing task based on the graph. As discussed above, in some embodiments, the graph-based image processing task may include a segmentation operation that can use the graph and one or more user annotations to segment the biological specimen image into a plurality of segments. The method may also include determining a set of different weights for the different image features, where the generation of the predefined number of clusters and the association of each superpixel with the cluster are based at least in part on the set of different weights.

In the foregoing discussion, various devices, engines, units, or blocks (e.g., some or all blocks system 100) were described as being implementable using hardware, software, firmware, or any combination thereof. It must be appreciated by a person skilled in the art in view of the foregoing discussion that the hardware may include any type of analog and/or digital circuitry, such as integrated circuits (IC) (e.g., application-specific integrated circuits (ASICs) or field-programmable gate arrays (FPGAs)), or any other type of special- or general-purpose electronic circuitry. It must be further appreciated by a person skilled in the art that the software or firmware may include any type of processor executable instructions that can be stored on any type of tangible non-transitory computer-readable medium, where the instructions can be executed by a processing resource, causing the processing resource to implement the functionality of the respective component.

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