As will be described in greater detail below, the present disclosure describes systems and computer-implemented methods for computer-generated and -executed automated workflows from media asset differentials. One of these computer-implemented methods may include accessing a first media data object and a different, second media data object that, when played back, each render temporally sequenced content. The method may also include comparing first temporally sequenced content represented by the first media data object with second temporally sequenced content represented by the second media data object to identify a set of common temporal subsequences between the first media data object and the second media data object. The method may further include identifying a set of edits relative to the set of common temporal subsequences that describe a difference between the temporally sequenced content of the first media data object and the temporally sequenced content of the second media data object. The method may then include executing a workflow relating to at least one of the first media data object and the second media data object based on the set of edits.