As discussed in 3GPP R4-1902146, the MSD for each EN-DC configuration may be a function of the separation between transmit and receive frequencies as well as the uplink and downlink bandwidths. The MSD for each UE may be different depending on implementation. For example, previously there was not sufficient isolation between TDD Band 41 and mid-spectrum FDD bands such as Band 25, Band 3 and Band 1 with earlier filters. However, more recent advances in technology have enabled integrated filter/multiplexer products to achieve sufficient isolation between TDD Band 41 and FDD Band 1 to allow for dual transmission in TDD Band 41 and FDD Band 1 uplink carrier aggregation with no MSD allowed.