One or more aspects of the subject disclosure include a device that includes a processing system including a processor and a memory that stores executable instructions. The executable instructions, when executed by the processing system, facilitate performance of operations that include determining a self-interference channel response of a transceiver of a mobile base station having a transmitter and a receiver. The self-interference channel response spans multiple sub-bands of a predetermined mobile cellular frequency channel. The operations further include selecting a first sub-band of the multiple sub-bands according to the self-interference channel response and determining, at the receiver, an estimate of a first coupled transmit power level of the transmitter when operating within the first sub-band. A sensitivity of the receiver is reduced according to the first coupled transmit power level to maximum receiver sensitivity, while also maintaining operation of the receiver within a substantially linear region to permit simultaneous transmission within the first sub-band and reception within a second sub-band of the plurality of sub-bands at the mobile base station.